Ethyl Cyanoacetate

Huihuang Chemical

Specifications

HS Code	349873
Chemical Formula	C5H7NO2
Molar Mass	113.115 g/mol
Appearance	Colorless to pale yellow liquid
Odor	Faint, sweet odor
Density	1.056 g/cm³ at 20 °C
Boiling Point	206 - 208 °C
Melting Point	-22 °C
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in ethanol, ether, chloroform
Flash Point	92 °C (closed cup)

Packing & Storage

Packing	Ethyl Cyanoacetate in 5 - liter containers, well - sealed for safe storage.
Storage	Ethyl cyanoacetate should be stored in a cool, dry, well - ventilated area, away from heat, sparks, and open flames as it is flammable. Keep it in a tightly sealed container to prevent vapor release. Store separately from oxidizing agents, acids, and bases to avoid chemical reactions. Use corrosion - resistant materials for storage containers.
Shipping	Ethyl Cyanoacetate is shipped in tightly - sealed containers, often made of corrosion - resistant materials. It's transported under proper temperature and humidity control to prevent decomposition, following strict chemical shipping regulations.

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General Information

Historical Development

Ethyl Cyanoacetate is an important raw material for organic synthesis. Its historical development can be traced back to the past, and organic chemistry was first developed at an early age, and various sages studied and explored it. At that time, organic synthesis was still unknown, but scholars were determined.
At the beginning, the preparation method of Ethyl Cyanoacetate was simple and the yield was meager. However, with the passage of time, the theory of organic chemistry has been improved day by day, and the experimental skills have also been refined.
Chemists have repeatedly tried, experimented, and improved the preparation method. Or find new reaction paths, or adjust the conditions of the reaction, so that the yield of Ethyl Cyanoacetate gradually increases and the quality is better. Its application in the field of organic synthesis has also narrowed and broadened, paving the way for the synthesis of many organic compounds, leaving a strong imprint in the long river of chemical development.

Product Overview

"Description of Ethyl Ester Cyanoacetic Acid"
Ethyl ester cyanoacetic acid is an important product in the chemical industry. Its shape is colorless liquid, has a specific fragrance, and its properties are relatively stable. It can also be changed in case of water, fire and strong acid and alkali.
The production method of this product is often obtained by esterification with cyanoacetic acid and ethanol as materials. It should be used in various fields and in the production of medicine. It is a raw material for synthesizing wonderful medicines; it is used in the production of pesticides to help prevent insects and control pests; and it is also used in the dyeing, weaving and fragrance industries.
The city is quite eager, because of its wide effect and indispensable. However, when it is used, it should be carried out in accordance with regulations, with emphasis on safety protection, so as not to hurt people, and to ensure that its quality and quantity are sufficient to meet the needs of various industries.

Physical & Chemical Properties

Ethyl Cyanoacetate is an organic compound with unique physical and chemical properties. It is a colorless to light yellow liquid with a slightly fragrant taste. From the perspective of physical properties, the boiling point is about 198-200 ° C, the relative density is 1.0560 (20/4 ° C), and the refractive index is 1.4175. This substance is soluble in ethanol, ether, and slightly soluble in water.
In terms of chemical properties, the presence of cyanyl and ester groups in Ethyl Cyanoacetate gives it active chemical activity. Cyanyl groups can undergo hydrolysis, reduction and other reactions, and ester groups can be hydrolyzed, alcoholized, and aminolyzed. For example, under basic conditions, ester groups are hydrolyzed to form cyanoacetate and ethanol; cyanyl groups can be converted into carboxyl groups by hydrolysis. Due to its properties, it is widely used in the field of organic synthesis and can be used as a key intermediate in the synthesis of medicines, dyes, and pesticides.

Technical Specifications & Labeling

"On the Technical Specifications and Labeling of Ethyl Cyanoacetate (Commodity Parameters) "
Ethyl cyanoacetate is a chemical substance. Its technical specifications are related to the preparation method and the accuracy of the ingredients. The preparation needs to follow a precise recipe, the compatibility of raw materials and the reaction conditions are all required. The proportion of ingredients must meet strict regulations, and the impurity content should be limited to trace amounts.
As for the label, the product parameters involved, such as the appearance and color, should be pure color, without variegated dyeing; the number of contents should be accurately measured to reach the specified standard; the physical parameters such as boiling point and melting point also need to conform to the specified range. These are all the technical specifications and labels of ethyl cyanoacetate, which are related to quality and cannot be ignored.

Preparation Method

Preparation of ethyl cyanoacetate
To make ethyl cyanoacetate, the choice of raw materials is crucial. Chloroacetic acid, sodium carbonate, sodium cyanide and ethanol are often used as the main raw materials. First, chloroacetic acid is neutralized with sodium carbonate to obtain sodium chloroacetate. This step requires moderate temperature control to make the reaction sufficient.
Then, sodium chloroacetate reacts with sodium cyanide to produce sodium cyanoacetate. This reaction is related to the purity of the product, and attention must be paid to the amount of sodium cyanide and the reaction conditions.
Furthermore, sodium cyanoacetate is esterified by ethanol to obtain ethyl cyanoacetate. In this esterification process, the reaction temperature and ethanol ratio all affect the yield.
The reaction steps are also exquisite, and each step needs to be closely connected. Neutralize first, hypocyanide, and then esterification in an orderly manner.
The catalytic mechanism cannot be ignored, and a specific catalyst can accelerate the reaction and improve the efficiency. Selecting a suitable catalyst and regulating it according to the reaction process is of great significance to improve the yield and purity. In this way, high-quality ethyl cyanoacetate can be prepared.

Chemical Reactions & Modifications

Ethyl Cyanoacetate is a commonly used raw material in organic synthesis. Its chemical reaction is changeable and involves many synthesis paths. In the past, the conventional yield was not ideal and the conditions were harsh.
Looking at the reaction, the traditional method may require high temperature and high pressure, and the choice of catalyst is limited, which causes frequent side reactions and affects the purity of the product. However, since the development of science, the method of change has gradually emerged.
New research is dedicated to improving the reaction conditions and finding efficient catalysts to improve the accuracy and yield of Ethyl Cyanoacetate reaction. If new nano-catalysts are used, the reaction temperature and pressure can be reduced, and side reactions can be reduced. This change not only optimizes the synthesis process, but also conforms to the concept of green chemistry, opening up a new path for the production of Ethyl Cyanoacetate, which is expected to cause far-reaching changes in the chemical industry and enhance its application value and economic benefits.

Synonyms & Product Names

Ethyl Cyanoacetate is also known as ethyl cyanoacetate. Its synonymous name is also known as ethyl cyanoacetate among merchants.
Looking at the past, all kinds of chemical products have their own names, and it is not uncommon to have different names for the same thing. Ethyl Cyanoacetate is also called differently in the industry, or depending on the origin or the use.
In chemical classics, it has also contained its synonymous name to help people understand its characteristics and uses. Although the names are different, the things it refers to are all this ethyl cyanoacetate. It has a wide range of uses in the field of chemical industry, either as a raw material or as an auxiliary agent, and has its own uses in various processes. Everyone should know its synonymous name and trade name in order to understand its application in chemical engineering.

Safety & Operational Standards

Code for the safe production and operation of ethyl cyanoacetate
Ethyl cyanoacetate is also an important product for chemical processing. To make this product, all matters must be detailed in the safety and operation specifications to ensure safety.
First word safety. Ethyl cyanoacetate is toxic and flammable. It is harmful to health when it is touched or smelled. When storing, it must be in a cool, dry and well-ventilated place, away from fire and heat sources. And it must be stored separately from oxidizing agents and alkalis to avoid its mixing and risk. The reservoir should also be tightly sealed to prevent its leakage.
Furthermore, the operation specification. When working, wear protective clothing, protective gloves and masks, and fully protect yourself before operating. When feeding, the dosage is accurate and the rate is uniform to prevent overreaction. The reaction temperature and pressure are strictly monitored and controlled, and if they are abnormal, they should be disposed of quickly. The stirrer runs smoothly, so that the materials are mixed evenly and the reaction is smooth.
Distillation and purification are related to quality and safety. Temperature control is appropriate to avoid overheating and explosion. Condensation device, with good effect, makes the distillate fully collected. The distilled liquid is properly stored.
As for waste, it cannot be disposed of at will. According to environmental protection regulations, it is collected by classification and is harmless in a proper place.
In short, the production of ethyl cyanoacetate is safety first, and the operation is in accordance with regulations to ensure smooth production, personnel safety, and the environment is clean. All kinds of norms, keep in mind, practice in practice, and there must be no slack.

Application Area

Ethyl Cyanoacetate is an important agent in organic synthesis. It is used in the field of medicine and can be used as a raw material for the synthesis of many drugs, such as synthetic antimalarial drugs, to help heal diseases. In terms of pesticides, it can produce high-efficiency insecticides and fungicides to protect crops from pests and diseases. In the dye industry, it is also a key intermediate, helping to form colorful dyes for printing and dyeing industries. And in the synthesis of fragrances, it is also useful, adding a unique aroma to fragrances. It is widely used and indispensable in many industrial fields. It is a treasure of chemical industry, bringing many conveniences and benefits to production and life.

Research & Development

The industry of chemical industry is changing with each passing day, and new products are coming out frequently. Ethyl Cyanoacetate is related to many fields of chemical industry, and its research and development is really what we are passionate about.
At the beginning, we explored the preparation method, but many times it was difficult. The selection of raw materials and the control of conditions all need to be carefully considered. After repeated tests, or due to temperature deviations, or due to improper proportions, the results were not obvious. However, my generation did not dare to slack off, and we continued to explore with tenacity.
After that, there was a breakthrough. Optimize the process, improve the process, the yield gradually increases, and the quality also becomes better. And its application scope is gradually expanded. In the synthesis of medicine, it is a key intermediate; in the preparation of materials, it also plays an important role.
Looking to the future, there is still a need for improvement. Strive for better methods, improve efficiency and reduce costs. Explore new uses, so that Ethyl Cyanoacetate can be used in more fields, bloom brilliance, and contribute to the development of chemical industry.

Toxicity Research

"Study on the Toxicity of Ethyl Cyanoacetate"
Taste the way of the doctor, investigate the source of the disease and seek the source, which is the most important thing for human life. Chemical substances also need to be scrutinized in detail in order to avoid harm and seek profit. Today, the toxicity of Ethyl Cyanoacetate should not be ignored.
Ethyl Cyanoacetate has a clear color and a different taste. Taste it with guinea pigs and white pigs, but when you enter the body, your qi and blood will be out of harmony. When guinea pigs are exposed to it, they can be seen that their fur is dull, their movements are slow, and they have asthma from time to time, which is a sign of lung damage; when white pigs are poisoned, their diet will gradually decline, their body will become thinner, and their visceral functions will decline. Looking at its toxicity, it can disturb the balance of yin and yang of the human body by entering through the mouth and nose, or seeping through the skin. Therefore, those who use this thing should strictly guard against protective gear and keep it in a well-ventilated place to prevent poisonous gas from invading the body, so as to protect their health.

Future Prospects

Ethyl Cyanoacetate is a crucial reagent in organic synthesis. Looking at its future development, the prospects are quite promising. In the field of medicine, with the deepening of disease research, the demand for new drug research and development may continue to grow. Because it can be used as a key intermediate to help synthesize a variety of specific drugs. In terms of pesticides, in order to meet the demand for high-efficiency and low-toxicity pesticides in food production, Ethyl Cyanoacetate will also play an important role. With its unique chemical properties, it can synthesize new pesticides to ensure a bumper crop. And with the advancement of science and technology, the synthesis process is expected to be optimized, the cost is reduced, and the quality is improved, thereby expanding its application scope. In this way, Ethyl Cyanoacetate will surely shine in various fields in the future and promote related industries to move forward vigorously.

Frequently Asked Questions

What are the main uses of Ethyl Cyanoacetate?

Ethyl cyanoacetate is widely used in organic synthesis. Its main users are synthetic heterocyclic compounds. Covered in the construction of many heterocyclic rings, ethyl cyanoacetate is often a key raw material. For example, in the synthesis of pyrimidine heterocyclic rings, ethyl cyanoacetate and urea are condensed under suitable conditions. After a series of reactions, pyrimidine derivatives can be obtained. Such derivatives are used in the field of medicine and are important intermediates for antibacterial, antiviral and other drugs.
Furthermore, it is also useful in the synthesis of fragrances. It participates in the reaction and can prepare compounds with unique aromas. Because ethyl cyanoacetate has a special chemical structure, it can introduce specific functional groups through various reactions, giving the product unique flavor characteristics. It is often an important starting material when preparing new fragrances.
And in the field of synthetic dyes, ethyl cyanoacetate is also indispensable. By reacting with different reagents, the skeleton structure of dye molecules is constructed. The cyanide group and ester group in its structure can be chemically converted, so that the resulting dye has good dyeing performance and color fastness.
And in the synthesis of pesticides, ethyl cyanoacetate is an important raw material for the preparation of a variety of pesticides. It can react with other organic reagents to obtain compounds with insecticidal, herbicide and other activities, which makes great contributions to agricultural production protection.
In summary, ethyl cyanoacetate plays an important role in many fields of organic synthesis. With it as a starting material, many compounds with important uses can be prepared through various reaction paths.

What are the physical properties of Ethyl Cyanoacetate?

Ethyl cyanoacetate is one of the most important organic compounds. Its physical properties are unique and are described in detail by you.
Looking at its appearance, under room temperature and pressure, ethyl cyanoacetate is a colorless to light yellow transparent liquid, just like a quiet spring, clear and tempting to explore. Its smell is also characteristic, emitting a slight mild aroma, not pungent, but it can also be perceived by people.
When it comes to boiling point, the boiling point of ethyl cyanoacetate is about 206 to 208 degrees Celsius. At this temperature, it is like a spirit that breaks free from bondage, sublimating from liquid to gaseous state. This boiling point characteristic makes it possible to achieve separation and purification by temperature regulation in specific industrial processes and experimental operations.
Besides the melting point, its melting point is about -22.5 degrees Celsius. When the ambient temperature drops to this temperature, the originally flowing liquid will gradually solidify into a solid state like time, showing a different form.
As for the density, the density of ethyl cyanoacetate is about 1.056 (g/mL, 20 ° C), which is slightly heavier than water. If it is placed in one place with water, it can be seen that it is like a stable stone, lying at the bottom of the water.
Solubility is also one of its important physical properties. Ethyl cyanoacetate is soluble in common organic solvents such as ethanol and ether, just like fish entering water, and the two blend seamlessly. However, its solubility in water is relatively limited, and it is only slightly soluble. This property is of great significance in the phase separation operation of organic synthesis.
In addition, the refractive index of ethyl cyanoacetate is about 1.4175 (20 ° C). When light passes through it, it is like magic and refracts. This property may play a wonderful role in the field of optical materials and analysis and detection.

Chemical Properties of Ethyl Cyanoacetate

Ethyl cyanoacetate is mild in nature and has unique chemical properties. Looking at its structure, it contains a cyanogen group (CN) and an ester group (COOEt), which give it a variety of chemical activities.
The ester group has the property of hydrolysis. Under the condition of acid or base catalysis, ethyl cyanoacetate can be hydrolyzed. Hydrolyzed in acid, cyanoacetic acid and ethanol are slowly produced; in alkali, cyanoacetic acid and ethanol are rapidly soluble in water. This hydrolysis reaction is a commonly used method for organic synthesis and can produce compounds containing carboxyl groups.
Cyanyl is also active. Ethyl cyanoacetate can be reduced to an amino group to obtain a product with an amino group, which is commonly used in the preparation of nitrogenous organic compounds. And the cyanyl group can undergo nucleophilic addition reactions, such as the addition of carbonyl groups with alaldehyde and ketone, to construct complex carbon skeletons, which are quite useful in the synthesis of polycyclic rings or chain compounds.
Furthermore, the α-hydrogen of ethyl cyanoacetate has certain reactivity. Because of the double electron-absorbing effect of cyano and ester groups, α-hydrogen is easy to leave in the form of protons to generate carbon negative ions. This carbon negative ion can react with electrophilic reagents such as halogenated hydrocarbons to achieve carbon chain growth, which is an important strategy for increasing carbon chains in the field of organic synthesis.
In summary, ethyl cyanoacetate is an important basic raw material in the field of organic synthesis due to its hydrolysis, cyano reduction and addition, and α-hydrogen activity. It is widely used in pharmaceutical, dye, fragrance and other industries.

What is the production method of Ethyl Cyanoacetate?

The method of making ethyl cyanoacetate is not detailed in ancient books, but today's chemical technology can be obtained. There are two common preparation methods.
First, chloroacetic acid is the beginning. First, the phase of chloroacetic acid and sodium carbonate is combined to obtain sodium chloroacetate. This step is the principle of acid-base neutralization. Then, the sodium cyanide is mixed with it, and at a specific temperature, the substitution reaction is carried out to obtain sodium cyanoacetate. The cyanyl group replaces the chlorine atom, and the chemical change is very delicate. At the end, sodium cyanoacetate is acidified with sulfuric acid, and then it is azeotropic with ethanol. After the process of esterification, ethyl cyanoacetate is obtained. Although the steps are complicated, the raw materials are easy to obtain, which is a common method.
Second, cyanoacetic acid and ethanol are used as materials. Sulfuric acid is added as a catalyst, and at an appropriate temperature, the reaction of esterification is carried out between the two. Acid and alcohol phase combine to remove water to form an ester, which is the general principle of esterification. After the reaction, after distillation and purification, impurities can be removed, and pure ethyl cyanoacetate can also be obtained. This step is slightly simpler, but refined cyanoacetic acid is required as the starting material, and the cost may be different.
Both of these are methods for preparing ethyl cyanoacetate. Chemists should choose the right one according to the factors of raw materials, cost and process.

Ethyl Cyanoacetate in Storage and Transportation

For ethyl cyanoacetate, many matters need to be paid attention to during storage and transportation.
The first word is storage, its nature is quite lively, and it needs to be placed in a cool and well-ventilated place. This is because the substance is prone to reaction when heated, and if stored in a warm place, it may change unexpectedly. The temperature of the warehouse must not be too high, and it should be maintained within a suitable range, so as to maintain the stability of its chemical properties. And it must be kept away from fire and heat sources. Pyrotechnics must not be near, because it is flammable, and it is easy to cause disasters in case of open flames.
Furthermore, the storage place should be separated from oxidants, reducing agents, acids, bases, etc., and must not be mixed. This is due to its chemical properties. When encountering such substances, it is easy to cause violent chemical reactions and endanger safety.
As for transportation, there are also many important rules. The packaging must be tight to ensure that there is no risk of leakage during the bumpy transportation. Transportation vehicles need to be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During driving, drivers must drive carefully to prevent collisions and overturns. During transportation, keep away from densely populated areas. If there is a leak, it will endanger many lives. When loading and unloading, the operator needs to pack lightly and handle it lightly, and must not treat it rudely to avoid leakage due to damaged packaging.
Overall, the storage and transportation of ethyl cyanoacetate is a matter of safety, and all details need to be taken care of carefully. A slight mistake could lead to a major disaster, which cannot be ignored.