Methyl Cyanoacetate

Huihuang Chemical

Specifications

HS Code	798749
Name	Methyl Cyanoacetate
Chemical Formula	C4H5NO2
Molar Mass	99.09 g/mol
Appearance	Colorless to light yellow liquid
Density	1.072 g/cm³ (20 °C)
Boiling Point	204 - 207 °C
Melting Point	-13 °C
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in ethanol, ether, etc.
Flash Point	102 °C
Odor	Faint, characteristic odor
Acidity Pka	10.7 (in DMSO)

Packing & Storage

Packing	1kg of Methyl Cyanoacetate packaged in a tightly - sealed, corrosion - resistant container.
Storage	Methyl cyanoacetate should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. It should be kept in tightly - sealed containers to prevent vapor leakage. Store it separately from oxidizing agents, acids, and bases. Use appropriate storage cabinets or areas designated for hazardous chemicals to ensure safety.
Shipping	Methyl Cyanoacetate is shipped in accordance with strict chemical regulations. It's typically packaged in sealed, corrosion - resistant containers. Transport is via approved carriers, ensuring proper handling to prevent spills and maintain safety during transit.

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General Information

Historical Development

Methyl cyanoacetate is also an organic compound. Its origin can be traced back to the beginning of chemical research. At that time, various sages worked hard to explore the field of organic synthesis.
In the early years, chemical experts based on cyano, acetate, etc., through complex reactions, the product was initially prepared. Although the initial production method was not good and the yield was not high, it laid the foundation for subsequent research.
Over the years, researchers improved their skills and improved their processes. By changing the reaction conditions or selecting new catalysts, the synthesis of methyl cyanoacetate became more and more perfect, and the yield gradually increased, and the purity was also good.
Today, it is widely used in medicine, pesticides, dyes and other industries. From the prototype of the past to today's important product, the evolution of this compound has also witnessed the process of chemical research, which has made great contributions to the prosperity of industry and the needs of people's livelihood.

Product Overview

Methyl cyanoacetate is also an important agent in organic synthesis. Its color is clear, the taste is slightly irritating, and it is a liquid at room temperature, with a certain volatility.
This product is prepared by the esterification reaction of cyanoacetic acid and methanol. It has a wide range of uses in the chemical industry and is a key intermediate in the synthesis of medicines, pesticides, dyes and many other products. In the synthesis of medicines, or involved in the preparation of specific drugs; in the field of pesticides, or the cornerstone of the creation of new pesticides.
However, this product is toxic and flammable, and safety procedures must be followed when using it. Storage should also be cautious, avoiding fire and oxidants, and placed in a cool and ventilated place to prevent accidents. Overall, although methyl cyanoacetate is of great significance in chemical production, its characteristics determine that it should be used and stored with caution.

Physical & Chemical Properties

Methyl cyanoacetate is an organic compound. It is a colorless and transparent liquid with a special odor. The boiling point is about 180 degrees, and the relative density is nearly one. It is soluble in organic solvents such as alcohols and ethers, and is difficult to dissolve in water.
Its chemical properties are active, and both cyanyl and ester groups are reactive. Cyanyl groups can undergo hydrolysis, addition and other reactions to convert into carboxyl groups or other nitrogen-containing functional groups. Ester groups can also be hydrolyzed to form corresponding acids and alcohols. Due to its special physical and chemical properties, it is widely used in the field of organic synthesis and is often an important raw material for the synthesis of drugs, pesticides and fine chemicals.

Technical Specifications & Labeling

"Technical Specifications and Labeling of Methyl Cyanoacetate (Product Parameters) "
The technical specifications and labeling of methyl cyanoacetate as described above. Its color should be clear and transparent, without visible impurities. Its content, measured by an accurate method, shall not be less than [X]%. The boiling point is about [specific value] ° C, and the density under [specific conditions] should be [specific value] g/cm ³.
On the label, the name "Methyl Cyanoacetate" should be stated, and a warning should be attached to inform it that it is toxic and dangerous. Packaging must be tight to prevent leakage. When storing, it should be placed in a cool, dry and ventilated place, away from fire and heat sources. These are all regulations designed to ensure the quality and safety of methyl cyanoacetate.

Preparation Method

"Preparation Method of Methyl Cyanoacetate"
Methyl cyanoacetate is also an important product in organic chemistry. The preparation method is related to raw materials, production processes, reaction steps and catalytic mechanisms.
The raw materials for preparation are often cyanoacetic acid and methanol. Sulfuric acid is used as a catalyst, and its temperature and pressure are controlled in a suitable container. First, cyanoacetic acid and methanol are put into the reaction kettle in a certain proportion, and sulfuric acid is introduced. Its catalytic effect makes the two play an esterification reaction.
The reaction steps are as follows: At the beginning, slowly heat up, so that the raw materials are fully mixed and contacted. During this period, the reaction state is closely observed, and the temperature and pressure are fine-tuned in a timely manner. When the reaction is stable, the product gradually emerges. Through distillation and purification, the impurities are removed to obtain pure methyl cyanoacetate.
The catalytic mechanism involves the dissociation of hydrogen ions by sulfuric acid, the activation of the molecules of cyanoacetic acid and methanol, the energy barrier of the reaction is lowered, the reaction is promoted, and the rate of product extraction is also high.

Chemical Reactions & Modifications

Methyl Cyanoacetate is also an organic compound. Its chemical reaction and modification are considerable. The reaction of this compound often involves nucleophilic substitution, and both cyanyl and ester groups are reactive, which can lead to various chemical transformations.
View its modification, or due to the introduction of new groups, to change its physical and chemical properties. If treated with specific reagents, ester groups can be transformed to obtain different functional groups, thereby changing their solubility and reactivity.
Or in the molecular structure, adjusting the type and position of substituents can cause changes in their biological activity and stability. In the field of organic synthesis, Methyl Cyanoacetate, with its unique reactivity and modifiability, is an important raw material for the preparation of various compounds, and has its applications in the pharmaceutical, pesticide and other industries.

Synonyms & Product Names

Methyl cyanoacetate is one of the chemical substances. Its name has the same difference, or methyl cyanoacetate, all referring to this substance. In the chemical industry, it has a wide range of uses and can be used as a raw material for organic synthesis, participating in many reactions, and is important for chemical manufacturing. Its properties are stable, colorless liquid, and has a specific odor. With its characteristics, it is used in medicine, pesticides and other fields. Knowing its similar name is convenient for industry communication, and the chemical industry can only be correct. This methyl cyanoacetate also helps industrial development.

Safety & Operational Standards

Methyl cyanoacetate is also a chemical product. If you want to make this substance, you should clarify its safety and operation specifications, so as to ensure that everything goes smoothly and there is no risk.
All operations involving methyl cyanoacetate are the first to be safe. Its substances are poisonous, and they can be damaged by touching, smelling or eating them. Therefore, when operating, you must wear protective equipment, such as gloves, masks, goggles, etc., to avoid contact with the body. And the place of operation should be well ventilated to avoid the accumulation of toxic gases.
As for the operation specifications, at the beginning of preparation, the amount of materials must be accurately measured, according to the square, and there should be no difference. The temperature and time of the reaction also need to be strictly controlled. The temperature is high or low, which affects the speed and fruit of the reaction; the length of time also affects the quality of the product. During operation, observe the reaction situation carefully. If there is any abnormality, take measures to deal with it quickly.
Storage of this thing also has its own rules. When placed in a cool, dry and ventilated place, avoid fire and heat. And store it separately from other things, especially oxidizing and acidic things, to prevent accidental transformation.
When handling, handle it with care to avoid shock, damage, and leakage. If it is unfortunate to leak, quickly isolate the scene, prohibit people from approaching, and take measures to clean the leak at the same time. For small leaks, absorb them with sand, vermiculite, etc.; for large leaks, contain and collect them and hand them over to professional offices.
In summary, the preparation, storage and transportation of methyl cyanoacetate are subject to safety and operating standards, so as to ensure the safety of personnel, protect the beauty of the environment, and promote the orderly production.

Application Area

"Methyl Cyanoacetate application field"
Methyl cyanoacetate is used in various fields. In the field of medicine, it is a key raw material for the synthesis of a variety of drugs. For example, the production of a certain type of antibacterial agent, which participates in the reaction, plasticizes the structure of the molecule, and makes the drug have better antibacterial effect.
In pesticides, it is also very important. It can be used to create new pesticides. After delicate chemical changes, pesticides are highly targeted and lethal to pests, and reduce their harm to the environment.
In the field of material synthesis, it can contribute to the synthesis of special materials. Such as synthesizing a polymer with unique properties, giving the material special physical and chemical properties, it can be used in cutting-edge fields such as electronics and aerospace. Therefore, methyl cyanoacetate is widely used and has important value in many industries.

Research & Development

Taste the chemical industry, the variety is rich, among which Methyl Cyanoacetate is particularly important. My generation devoted himself to studying its quality, properties and uses.
Initially study its quality, in the experimental environment, observe its shape in detail, know its shape and color, and understand its basic characteristics. Then study its nature, observe its response to various things, observe its changes at different temperatures and pressures, and understand its chemical properties.
As for its application, it is a key material in the field of pharmaceuticals, helping to become a good medicine and help people with illness; in the industry of dyeing and weaving, it also has its use, adding color and brilliance.
We are determined to use our in-depth research to promote the development of this product. Explore new ways, seek the best method, hope its efficiency is better, the wider the application, in the chemical industry, the bright light, for the prosperity of the industry, do our best.

Toxicity Research

"Study on the Toxicity of Methyl Cyanoacetate"
Those who taste chemical products and methyl cyanoacetate have different characteristics and are related to the study of toxicity.
Methyl cyanoacetate has a clear color and different taste. Its way into the body, either through the skin, or by breathing, or due to food ingestion. Those who have tasted the researchers, took the white mice as an experiment, and fed them with something containing methyl cyanoacetate. Not long after, the white mice were restless, trembling and eating less, and it was known that this substance disturbed their physiology.
Looking at its toxicology, when methyl cyanoacetate is exposed to water or heat, it can explain the poison, invade human cells, disorderly metabolic order, and damage the function of organs. Especially in the liver and kidney, causing its dysfunction.
In summary, methyl cyanoacetate is significantly toxic, and it must be strictly prevented and controlled for production.

Future Prospects

Methyl cyanoacetate is a wonderful chemical product today. It has great uses in industry and medicine. In the future, the development of this product is immeasurable.
In the field of industry, methyl cyanoacetate can be an essential material for the synthesis of various fine chemicals. With the development of science and technology, the purity and output required by industry are gradually increasing. With time, there will be ways to greatly increase its yield, improve its quality, and help the progress of industry.
The way of medicine also depends on a lot. It can be used as an intermediate for medicine and synthesize special drugs. The needs of future medical care are increasingly numerous, and the research on its quality and characteristics must be deepened. Or according to its nature, a better medicine can be made to save people's diseases.
Therefore, the future of methyl cyanoacetate is like the first light of dawn, the light is waiting to be developed, and the future development can be expected.

Frequently Asked Questions

What are the main uses of Methyl Cyanoacetate?

Methyl cyanoacetate, as well as organic compounds, has a wide range of uses.
In the field of medicine, it is often the key raw material for the synthesis of drugs. Such as the preparation of certain antimalarial drugs, sedatives, etc., methyl cyanoacetate can be converted into structural units with specific pharmacological activities through a series of reactions, which help to construct drug molecules to achieve the purpose of treating diseases.
In terms of pesticides, it is an important intermediate for the synthesis of a variety of high-efficiency pesticides. It can participate in the synthesis of pesticides, fungicides, etc. By reacting with other compounds to generate pesticide ingredients with strong biological activity, which can effectively kill pests, control crop diseases, and protect farmers and produce a good harvest.
In the dye industry, methyl cyanoacetate is also useful. It can be used as a raw material for the synthesis of specific dyes. After ingenious chemical reactions, dyes with brilliant colors and excellent properties are produced, which are used for dyeing fabrics, leather, etc., to make their colors bright and lasting.
In addition, in the field of organic synthesis, methyl cyanoacetate is a highly active reagent, which provides convenience for the synthesis of complex organic compounds. Because of its functional group properties, it can participate in a variety of organic reactions, such as condensation reactions, substitution reactions, etc., helping chemists construct diverse and complex organic molecular structures and promoting the development of organic synthesis chemistry.

What are the physical properties of Methyl Cyanoacetate?

Methyl cyanoacetate is an organic compound. It has many physical properties and is described below.
Looking at its properties, methyl cyanoacetate is a colorless to slightly yellow liquid under normal conditions, and its shape is flowing and clear. Smell it, it has a slightly irritating smell, but it is not very strong.
When it comes to the melting point, the melting point of methyl cyanoacetate is about -22 ° C, and the boiling point is 204-207 ° C. Because of its low melting point, it is a liquid at room temperature, and the boiling point is relatively high. To make it boil and vaporize, a higher temperature is required.
As for the density, it is about 1.122g/cm ³, which is slightly higher than the density of water, so if mixed with water, methyl cyanoacetate will sink underwater.
In terms of solubility, methyl cyanoacetate is slightly soluble in water, but it can be miscible with organic solvents such as ethanol and ether. This property has both polar groups and non-polar parts in its molecular structure, resulting in weak interaction with water and good compatibility with organic solvents.
In addition, the vapor pressure of methyl cyanoacetate is relatively low, the volatility is not very strong, and it is less volatile into the air at room temperature and pressure. And because of its certain chemical activity, it is necessary to pay attention to its stability when storing and using it, and avoid high temperatures, open flames, and oxidants to prevent chemical reactions or safety accidents.

Chemical Properties of Methyl Cyanoacetate

Methyl cyanoacetate is an important raw material in organic synthesis. Its chemical properties are unique and have many remarkable characteristics.
First, the reactivity of cyanyl groups is quite high. Cyanyl groups can undergo hydrolysis, and under the catalytic conditions of acids or bases, cyanyl groups can be gradually converted into carboxyl groups. When hydrolyzed in an acidic medium, an amide intermediate is formed first, and then further hydrolyzed into cyanoacetic acid. If the reaction continues, cyanoacetic acid can continue to be hydrolyzed to form products such as acetic acid and carbon dioxide; hydrolyzed under alkaline conditions, cyanoacetic acid will be formed, and cyanoacetic acid can be obtained after acidification. This hydrolysis property is often used in organic synthesis to construct compounds containing carboxyl groups.
Second, ester groups also have specific reactivity. Ester groups can undergo alcoholysis reactions, and with different alcohols under the action of catalysts, new esters and original alcohols can be generated. This reaction is widely used in the preparation of esters with specific structures. At the same time, ester groups can also undergo hydrolysis reactions, under acidic or basic conditions, hydrolysis to generate corresponding acids and alcohols. Hydrolysis is more complete under alkaline conditions, which is called saponification reaction, and is often used for the analysis of esters and the preparation of corresponding acids.
Third, the α-hydrogen in the methyl cyanoacetate molecule has a certain acidity. Due to the electron-absorbing induction effect of cyano and ester groups, α-hydrogen is relatively active and easy to leave under the action of bases, and then nucleophilic substitution or nucleophilic addition reactions occur. For example, it can undergo condensation reactions with alcaldes, ketones, etc., to form new carbon-carbon bonds, which are used in organic synthesis to grow carbon chains and build complex organic structures.
Fourth, methyl cyanoacetate can participate in nucleophilic substitution reactions. The presence of cyanyl and ester groups changes the electron cloud distribution of the molecule, and the carbon atom has a partial positive charge, which is vulnerable to attack by nucleophiles. Nucleophiles can replace some groups in the molecule to realize the transformation of functional groups and the synthesis of new compounds.
In summary, methyl cyanoacetate has active and diverse chemical properties, and has broad application prospects in the field of organic synthetic chemistry. It can be used to prepare a variety of drugs, pesticides and other fine chemicals.

What is the production method of Methyl Cyanoacetate?

The preparation method of methyl cyanoacetate was mostly obtained by esterification of cyanoacetic acid and methanol in the past.
First take an appropriate amount of cyanoacetic acid, place it in the reactor, and slowly add methanol. The ratio of the two should be precisely prepared according to stoichiometry. A little excess of methanol is appropriate. The lid can promote the esterification reaction to the direction of generating methyl cyanoacetate.
Next, add an appropriate amount of catalyst, commonly used as a protonic acid such as sulfuric acid. The catalyst can effectively reduce the activation energy of the reaction and speed up the reaction rate. The reaction process needs to be temperature controlled, generally in a moderate temperature range, such as 60-80 degrees Celsius. If the temperature is too high, the product will be impure due to side reactions; if the temperature is too low, the reaction rate will be slow and time-consuming.
When reacting, stir to make the reactants fully contact and the reaction will be more uniform. When the reaction reaches a predetermined time, sample and test to observe the reaction process. If the reaction is basically complete, the subsequent steps of separation and purification are required.
First, neutralize the acidic catalyst in the system with basic substances, such as sodium carbonate solution, etc., until the solution is neutral or slightly acidic. Then perform distillation, using the difference in boiling points between methyl cyanoacetate and other impurities to steam out methyl cyanoacetate. The product obtained by initial steaming or containing a small amount of impurities can be rectified to obtain high-purity methyl cyanoacetate.
In addition, there are also those who use chloroacetic acid as the starting material. First, chloroacetic acid is reacted with sodium cyanide to form cyanoacetic acid. This step needs to be carried out under suitable reaction conditions, such as controlling the reaction temperature, pH value, etc., to ensure the smooth cyanide reaction. Then the obtained cyanoacetic acid and methanol are esterified according to the above method to make methyl cyanoacetic acid. Although this approach is a little complicated, the raw materials are easy to obtain, and it is also a common preparation method.

What are the precautions for Methyl Cyanoacetate during use?

Methyl cyanoacetate is an important raw material in organic synthesis. During use, many aspects must be paid attention to.
Bear the brunt, and safety is of paramount importance. Methyl cyanoacetate is toxic and irritating to a certain extent, and can cause damage to the human body if it touches the skin, eyes or inhales its vapor. Therefore, when operating, protective measures must be taken. Wear protective clothing, protective gloves and goggles, and ensure that the operating environment is well ventilated to prevent vapor accumulation. In case of accidental contact, rinse with plenty of water immediately and seek medical assistance according to the specific situation.
Furthermore, storage is also exquisite. It should be stored in a cool, dry and ventilated place, away from fire and heat sources. Due to its flammability, it needs to be stored separately from oxidants, acids, alkalis, etc., and must not be mixed to avoid dangerous chemical reactions. At the same time, the storage area should be equipped with suitable materials to deal with possible leakage accidents.
When using, accurate measurement and operation are also key. Because it is an important synthetic raw material, accurate dosage is related to the effectiveness of the reaction and product quality. The operation process must follow the established operating procedures and process requirements, and strictly control the reaction conditions, such as temperature, pressure, reaction time, etc.
In addition, the disposal of waste should not be underestimated. Waste after use must not be discarded at will, and it needs to be properly disposed of in accordance with relevant regulations to prevent pollution to the environment. Waste should be collected in a specific container and handled by a professional organization for harmless disposal.
In conclusion, when using methyl cyanoacetate, care must be taken in terms of safety, storage, handling, and waste disposal to ensure the safety and efficiency of the use process.