What are the main uses of 4,6-dihydroxypyrimidine?
The main use of 4,6-diaminopyrimidine is in the fields of medicine, pesticides and other chemicals.
In the way of medicine, it is the key raw material of traditional Chinese medicine. The preparation of many antibacterial and antiviral drugs relies on this as the basis. For example, some good medicines for the treatment of malaria, 4,6-diaminopyrimidine is involved, and with its special chemical structure, it can effectively inhibit the growth and reproduction of malaria parasites and achieve therapeutic effect. And when developing new antibacterial drugs, it is often used as the starting material, chemically modified and modified to obtain new compounds with stronger antibacterial activity and selectivity, which are powerful weapons for human beings to fight against the invasion of pathogens.
In the field of pesticides, 4,6-diaminopyrimidine is also important. Pesticides made from it have good control functions against many crop pests and pathogens. It can interfere with the physiological and metabolic processes of pests or pathogens, hinder their growth and development, ensure the healthy growth of crops, improve crop yield and quality, and greatly assist agricultural production.
In addition, in other chemical industries, 4,6-diaminopyrimidine can be used as an intermediate in organic synthesis. After a series of chemical reactions, a variety of organic compounds can be derived for the preparation of dyes, pigments, polymer materials, etc. For example, in the synthesis of dyes, their structural characteristics can endow dyes with unique color and stability, expanding the variety and application range of chemical products.
From this perspective, 4,6-diaminopyrimidine has important uses in many fields and has made great contributions to the development of medicine, agriculture and chemical industries.
What are the synthesis methods of 4,6-dihydroxypyrimidine?
4,6-Dinitrobenzoic acid is an important intermediate in organic synthesis. There are many synthesis methods. Throughout the ages, all kinds of ingenuity have converged. The following are common methods:
1. ** Nitrification method using benzoic acid as raw material **:
- This is a classic production method. Benzoic acid undergoes nitrification under the action of mixed acids (sulfuric acid and nitric acid in a certain proportion). Geyin benzene ring has electron-rich properties and is vulnerable to attack by electrophilic reagents. Nitric acid generates nitroyl positive ion (NO 🥰) in a strongly acidic environment provided by sulfuric acid. This is an electrophilic reagent that attacks benzoic acid benzene ring. Due to the carboxyl group being the meta-localization group, nitroyl positive ions mainly attack the 3,5-position of the benzene ring, resulting in 4,6-dinitrobenzoic acid. For example, put an appropriate amount of benzoic acid into a reactor equipped with a condensation reflux device, slowly add carefully prepared mixed acids, control the reaction temperature in a certain range, and react for several hours. After the reaction is completed, through cooling, crystallization, filtration, washing and other processes, the crude product can be obtained, and then recrystallized and purified to obtain high-purity 4,6-dinitrobenzoic acid.
2. ** Multi-step synthesis method starting from toluene **:
- First, toluene is nitrified with a mixed acid of concentrated nitric acid and concentrated sulfuric acid. Since methyl is an o-para-localization group, a mixture of o-nitrotoluene and p-nitrotoluene can be obtained. After separation means (such as distillation, crystallization, etc.) to obtain o-nitrotoluene, then o-nitrotoluene is oxidized under specific conditions with strong oxidants such as acidic potassium permanganate solution, methyl is oxidized to carboxyl groups to obtain o-nitrobenzoic acid. Then the o-nitrobenzoic acid is twice nitrified, and under suitable conditions, 4,6-dinitrobenzoic acid can be obtained. Although this process is complicated, the raw material toluene is cheap and easy to obtain, and has certain applications in industrial production.
3. ** Synthesis method using other derivatives as raw materials **:
- For example, using 4-nitrobenzoic acid as raw material, re-nitrification, by controlling the reaction conditions, the nitro group is mainly introduced into the 6-position to obtain 4,6-dinitrobenzoic acid. Or using 2,4-dinitrotoluene as raw material, through oxidation step, methyl is oxidized to carboxyl group, and the target product can also be obtained. Such methods are valuable in specific situations depending on the source of raw materials and the convenience of reaction conditions.
What are the physical and chemical properties of 4,6-dihydroxypyrimidine?
For 4,6-dinitrobenzoic acid, its physicochemical properties are very specific. The outer surface of this substance is often light-colored and crystalline, and under normal conditions, its properties are determined.
In terms of solubility, it is soluble in water, but soluble in many soluble substances, such as ethanol and ether. The solubility characteristic is determined by its molecules. Its molecules contain nitro isogroups, causing its water molecules to form an effective interaction, so it is soluble in water; and the compatibility of soluble molecules can be dissolved by molecular force.
The melting value of 4,6-dinitrobenzoic acid has a test value of 182-184 ℃. At this point in time, the crystals disintegrate, and the solids and liquids dissolve. This melting characteristic, its preparation, determination, and other operations are extraordinary. For the purpose of this melting, it can be based on this melting, by controlling the degree for the purpose of separation; the determination of the melting is also important. If the fusion of the material is consistent with the known melting of 4,6-dinitrobenzoic acid, it can be preliminarily determined that it may be this material.
In addition, the chemical properties of this material can also be described. The nitro activity in its molecules is high, and it is easy to be mixed and reversed. In case of the original, the nitro group can be formed to derive compounds containing amino groups. This reaction has a wide range of uses in the field of synthesis, and can be used to synthesize a series of compounds with special functions. And because of its acidic group, it can also be neutralized and reversed to generate a phase. This anti-reaction property makes 4,6-dinitrobenzoic acid have a place in many chemical processes, and can be used in synthetic compounds, dyes and other products.
What is the price of 4,6-dihydroxypyrimidine in the market?
The market price of 4,6-diaminopyrimidine is difficult to determine quickly. The price of the cap often changes for various reasons.
First, the price is determined by supply and demand. If there are many people in the market, but the supply is small, the price will necessarily increase. On the contrary, if the supply exceeds the demand, the price may drop. For example, if the demand for 4,6-diaminopyrimidine in the pharmaceutical industry increases sharply, because it is an important raw material for the production of certain drugs, manufacturers are competing for it, but the output does not increase accordingly, and the price rises.
Second, the price of raw materials also has an impact. The production of 4,6-diaminopyrimidine requires specific raw materials. If the price of these raw materials increases, the production cost will increase, and the price of the finished product will also increase. If the raw materials are affected by natural disasters, geopolitics, etc., the output will decrease and the price will increase, and the price of 4,6-diaminopyrimidine will also rise.
Third, the process and technology are related to cost and quality, which in turn involves its price. New and excellent processes may reduce costs and improve quality, and the price may be stable and moderate; if the process is outdated, the cost is high and the quality is not good, and the price may be high.
Fourth, the trend of market competition cannot be ignored. If the market is controlled by a few manufacturers, the price may be maintained at a higher level.
Therefore, in order to know the current market price of 4,6-diaminopyrimidine, it is necessary to observe the market supply and demand, raw material prices, process progress and competition landscape in real time to know its price.
What are the storage conditions for 4,6-dihydroxypyrimidine?
4,6-Dinitrobenzoic acid is a strong explosive component, and its storage conditions are quite strict.
These items should be placed in a cool, dry and well-ventilated place. Because it is extremely sensitive to heat, friction and impact, if the storage environment temperature is too high, or due to improper operation caused by friction and impact, it is easy to trigger an explosion, resulting in serious disasters.
Furthermore, be sure to keep away from fire sources, heat sources and all kinds of oxidizing substances. Fire sources and heat sources will increase the temperature and enhance their reactivity; oxidizing substances in contact with them may cause violent chemical reactions and increase the risk of explosion.
Storage places must have perfect fire, explosion and lightning protection facilities. Fire protection facilities can be put out in time to prevent the spread of fire in the event of accidental fire; explosion-proof facilities can reduce the degree of damage in the instant of explosion; lightning protection facilities can prevent accidents caused by lightning.
And the storage place should be equipped with obvious warning signs to warn everyone that there are dangerous goods here and do not touch them.
At the same time, the relevant management personnel must undergo professional training, be familiar with its characteristics and safe storage methods, and strictly follow the operating procedures. Regular inspections should be carried out to ensure that the environment is stable and the packaging is not damaged. Once any abnormalities are found, they should be properly disposed of immediately. In this way, the safety of 4,6-dinitrobenzoic acid storage can be guaranteed to the greatest extent to avoid major accidents.