The method of preparing 2-hydroxy-2-phenylacetic acid
If you want to prepare 2-hydroxy-2-phenylacetic acid (2-hydroxy-2-phenylacetic Acid), follow the method of 2-hydroxy-2 Phenylacetic Acid.
First take an aryl halide, make it meet with magnesium chips in an anhydrous ether, stir it, and form a Grignard reagent. This Grignard reagent is quite active and can be communicated with carbon dioxide to obtain a carboxylation product. Thereafter, hydrolyze it with dilute acid to obtain 2-hydroxy-2-phenylacetic acid.
Or take acetophenone, oxidize it with peroxide, and change it by rearrangement, you can also get this acid. The method is to take an appropriate peracid as an agent, add acetophenone, complete the reaction, hydrolyze it, and 2-hydroxy-2-phenylacetic acid is formed.
Furthermore, under the catalysis of benzaldehyde and malonic acid in a weak base, condensation is carried out, and then decarboxylation can also be prepared. This is the way to make 2-hydroxy-2-phenylacetic acid, each has its own convenience, depending on the material and conditions.