Whether azelaic acid and glycolic acid can be used in combination for the treatment of
skin, and the way of medication needs to be carefully reviewed. Azelaic acid and glycolic acid are both agents used in skin care. However, whether the two can be applied together, it is necessary to investigate their properties and observe their effects.

Azelaic acid has the ability to inhibit bacteria, can reduce the proliferation of Propionibacterium acne, and can adjust skin keratinization and make pores smooth. It can also lighten pigmentation and smooth skin tone, because it can inhibit the activity of tyrosinase.

Glycolic acid, a fruit acid and the like, is mild in nature, can exfoliate the cuticles, make the old cells on the surface of the skin fall off, promote new cells, and make the skin smooth and delicate. And it can increase skin hydration, improve fine lines and roughness.

As for the combination of the two, there are advantages and concerns. Benefits, synergistic effect. After exfoliation of glycolic acid, it can help azelaic acid better penetrate into the deep layers of the skin, enhance the effect of bacteriostatic and light spots; azelaic acid adjusts keratinization, and also creates a good environment for glycolic acid to play a role in promoting skin rejuvenation.

However, there are also concerns. Both are irritating to the skin. Glycolic acid thins the stratum corneum and reduces the skin's defense; azelaic acid may also cause skin discomfort, such as tingling, redness, itching, etc. If used in combination, irritation is superimposed, sensitive skin may be intolerable, and even cause skin damage, such as redness, swelling, desquamation, and damage to the barrier.

Therefore, if you want to use azelaic acid and glycolic acid in combination, you should first check the nature of the skin. If the skin is well tolerated, you can try it on a small scale to observe the skin reaction. Use low concentrations first, and gradually increase the concentration and frequency. If the skin is sensitive, be careful, you can consult a doctor or skin care expert, and follow their words to ensure the safety of the skin and seek the effect of skin care.