On the method of diethyl malonate
Diethyl malonate is also an important agent for organic synthesis. Its formula is $C_7H_ {12} O_4 $, the structure is exquisite, the ester group is contained, and the activity is different.

Looking at its preparation method, it is often obtained by chloroacetic acid as the beginning, after alkalization, cyanidation, and then esterification. When chloroacetic acid encounters alkali, the carboxyl group forms a salt, and the cyanide ion nucleophilic replaces halogen to obtain cyanoacetic acid. After co-heating with ethanol and sulfuric acid, the esterification reaction is completed, and the diethyl malonate is formed.

As for the application, it has an extraordinary effect in the field of organic synthesis. Because methylene is affected by diester groups and has active hydrogen, it can react with strong bases to form carbon negative ions. This carbon negative ion has strong nucleophilicity and can react with halogenated hydrocarbons, carbonyl compounds and other electrophilic reagents. If it reacts with halogenated hydrocarbons, alkyl groups can be introduced, hydrolyzed and decarboxylated to replace acetic acids. Or it can be condensed with carbonyl compounds to build a complex carbon skeleton, paving the way for the synthesis of many organic compounds.

In addition, diethyl malonate is also a common raw material in drug synthesis, fragrance preparation and other industries. The key structure of many drugs and fragrances depends on its participation in the synthesis. Due to its unique structure and active properties, diethyl malonate plays an important role in the synthesis of organic chemistry, promoting the progress of organic synthetic chemistry and benefiting many industries.