Method of diethyl malonate to carboxylic acid
Diethyl malonate. To make carboxylic acid, the method has a diameter. First, the sodium alcohol is used, and the sodium alcohol has strong properties. It can take away the hydrogen of methylene in diethyl malonate and form carbon negative ions. This negative ion has high activity and can be nucleophilic substituted with halogenated hydrocarbons. The hydrocarbons are based on the structure of diethyl malonate.

times, through the process of hydrolysis. Using acid or base as catalyst, the ester group of diethyl malonate is hydrolyzed to form malonic acid derivatives. Malonic acid derivatives have poor stability and are easy to decarboxylate when heated.

When heated, the malonic acid derivative loses one molecule of carbon dioxide and finally obtains the target carboxylic acid. In this process, the introduction of hydrocarbon groups determines the structure of the carboxylic acid, and the appropriate halogenated hydrocarbons are selected according to the desired carboxylic acid structure. Through this series of reactions, the purpose of preparing specific carboxylic acids from diethyl malonate can be achieved.