The reaction of ethyl cyanoacetate with cyclohexanone and sodium ethyl alcohol

The combination of ethyl cyanoacetate and cyclohexanone with sodium ethyl alcohol is the main way of organic synthesis. Sodium ethyl alcohol is active and often acts as a catalyst in the reaction system, which can initiate the end of chemical change.

Ethyl cyanoacetate has a special functional group. The coexistence of cyanyl and ester groups makes it have the characteristics of both nitrile and ester. Cyclohexanone contains carbonyl groups, which is the activity check point of nucleophilic addition. The ethoxyl group of sodium ethyl alcohol is nucleophilic and can attack the ester group of ethyl cyanoacetate, so that its structure is rearranged, and then nucleophilic addition occurs with the carbonyl group of cyclohexanone.

Initially, the ethoxy group of sodium ethanol attacks the carbonyl group of ethyl cyanoacetate ester, forming an unstable intermediate. This intermediate is rapidly rearranged to release ethanol molecules, and at the same time, a more active carbonegative ion is formed. The carbonegative ion then attacks the carbonyl carbon of cyclohexanone, forming a new carbon-carbon bond.

With the evolution of the reaction, proton transfer and dehydration take place in the molecule, and a complex product structure is gradually constructed. The final product has a wide range of applications in the field of organic synthesis chemistry due to different reaction conditions, or with various configurations and functional group modifications. It can be used as a key intermediate in drug synthesis, material preparation, etc.

Looking at this reaction, we can see the wonders of organic chemistry, the interaction of reactants, and the construction of complex and delicate molecular structures according to chemical laws, opening up a broad path for chemical research and practical applications.