Synthesis of ethyl cyanoacetate
If you want to make ethyl cyanoacetate, you need to understand the method. In the past, Fang family explored various paths to find the best method.

The first method is to use cyanoacetic acid and ethanol as materials, add catalytic agents to control the temperature. Make the two phase combine, and after time, when it is finished, use distillation to remove its impurities to obtain ethyl cyanoacetate. In the meantime, the catalytic agent is especially important, and the advantages and disadvantages are related to the yield. The good ones promote the reaction speed, and the yield is high; the bad ones are the opposite.

There is another method, starting with ethyl chloroacetate and sodium cyanide. First, ethyl chloroacetate is prepared, and then it encounters with sodium cyanide and replaces it in a suitable environment. Of course, sodium cyanide is highly toxic, so you must be careful to prevent it from leaking and protect your health. After that, it is also separated and purified to make the product pure.

There are also those based on hydrogen cyanide, acetaldehyde and ethanol. Hydrogen cyanide combines with acetaldehyde to obtain cyanoethanol, and then reacts with ethanol under catalysis to form ethyl cyanoacetate. The raw material hydrogen cyanide is also toxic in this way, and it should be strictly followed to avoid disasters.

All kinds of methods have advantages and disadvantages. Good observation of its situation, the right to the severity, and the right to follow, can be used in the synthesis of ethyl cyanoacetate, and get good results to meet all needs.