On the relationship between glycolic acid and acanthosis nigricans
Modern physicians have been deeply researching various diseases of the skin. In acanthosis nigricans, the skin becomes thicker, pigmented, and gray-black in color, like velvet, common in the folds of the neck, axils, groin, etc. Its etiology is complex, or related to endocrine disorders, obesity, genetics, and certain diseases.

Glycolic acid belongs to the category of α-hydroxy acids, which are widely used in the field of skin care. Its molecules are tiny, which can smooth the stratum corneum, loosen the bridging particles between keratinocytes, promote the shedding of old keratin, and accelerate the renewal of the skin's surface. And glycolic acid can increase the hydration ability of the skin and make the skin moist.

Looking at the relationship between it and acanthosis nigricans, it is due to the thickening of the stratum corneum of the skin with acanthosis nigricans and the disorder of cell turnover. Glycolic acid can use its function of loosening the keratin and promoting cell renewal to improve the thick keratin state of the skin with acanthosis nigricans. There are also clinical cases. When used externally with glycolic acid preparations, over time, the skin affected by acanthosis nigricans gradually smoothes and the pigmentation decreases.

When administered, it should also be cautious. Glycolic acid has a certain irritation, and different individuals have different tolerances. When first used, there may be skin tingling and redness. Therefore, before treatment, it is necessary to carefully observe the skin characteristics of the patient, try it on a small scale, gradually increase and increase the frequency, and instruct the patient to take proper care to prevent sunlight exposure to avoid skin damage.

In summary, glycolic acid has great potential in the treatment of acanthosis nigricans. However, doctors should weigh the pros and cons according to the actual situation of the patient, and apply accurate treatment in order to achieve the ideal effect and solve the dilemma of the patient's skin.