On the Interaction between Glycolic Acid and Isotretinoin
In modern medicine, it is related to the nourishment and treatment of the skin. Glycolic acid and Isotretinoin are both commonly used. However, when the two are used together, the interaction between them should be well understood by both doctors and patients.

Glycolic acid is an alpha-hydroxy acid. On the outer layer of the skin, it can loosen the connection between keratinocytes, promote keratin renewal, and make the skin smooth and tender. It can also increase skin hydration, lighten pigmentation, and improve skin texture. It is often seen in various skin care preparations.

Isotretinoin, which is mostly used to treat severe acne. It can regulate the secretion of sebaceous glands, inhibit the keratinization of hair follicles, and reduce the growth of Propionibacterium acne, with significant effect. However, it is strong and has many adverse reactions.

When glycolic acid and isotretinoin are applied together, the risk is numerous. Glycolic acid not only promotes exfoliation, but also isotretinoin has this ability. The superposition of the two increases the irritation of the skin sharply. In light cases, the skin is reddish, burning, and itchy; in severe cases, it may cause peeling, erosion, and damage the skin barrier.

Furthermore, the use of both may increase the percutaneous absorption of isotretinoin. Isotretinoin has many adverse reactions, such as teratogenicity, damage to liver function, and abnormal blood lipids. With increased absorption

Therefore, when the doctor is taking medication, the patient's condition should be carefully reviewed. If isotretinoin is being used, it is not necessary, and glycolic acid products should not be used. Patients should also follow the doctor's advice and do not mix them by themselves to ensure healthy skin.