On the mechanism of action of sodium thiosulfate in cyanide poisoning
Cyanide poisoning, its toxicity is fierce and dangerous, and quick rescue is necessary. Sodium thiosulfate has a unique and key mechanism of action in the treatment of cyanide poisoning.

The toxicity of cyanide is mainly due to the close combination of cyanide ions (CN) and trivalent iron ions in cytochrome oxidase, which inactivates the enzyme, blocks the electron transfer of the cellular respiratory chain, and makes cells unable to use oxygen, causing asphyxiation in tissue cells, endangering life.

Sodium thiosulfate can dissolve this poison, mainly because of its sulfur-containing groups. In the body, sodium thiosulfate can provide sulfur atoms through the action of thiocyanase. After the cyanide ion obtains this sulfur atom, it is converted into thiocyanate. This process is as follows: sodium thiosulfate (Na ² S ³ O 🥰) is catalyzed by thiocyanase, and its sulfur atoms are transferred to cyanide ions (CN) to form thiocyanate (SCN). Thiocyanate is much less toxic than cyanide, and can be excreted from the body through the kidney and urine, thereby attenuating and detoxifying, and helping the body recover.

Furthermore, sodium thiosulfate can regulate the oxidation-reduction balance in the body. Cyanide poisoning often causes disorder of the oxidation-reduction system in the body, increasing the number of reactive oxygen species, and damaging the structure and function of cells. Sodium thiosulfate is reductive and can participate in the oxidation-reduction reaction in the body, remove excessive reactive oxygen species, slow cell damage, and protect the normal function of cells. It is also of great significance for the treatment of cyanide poisoning.

In summary, sodium thiosulfate has a significant therapeutic effect on cyanide poisoning by providing sulfur atoms to promote cyanide ion conversion and regulating oxidation-reduction balance, and is a key drug for detoxification. In clinical cases of cyanide poisoning, sodium thiosulfate should be used immediately to save lives.